My wife and I flew Qatar Airways business class from Karachi to San Francisco in April 2021. It was during pandemic but after vaccines were out. We went (we took Turkish on the way out) exactly two weeks after getting our shots. I used American Airlines miles to book this ticket, it cost 70k points.
This journey consisted of two legs: Karachi to Doha on a 787 Dreamliner and Doha to San Francisco on a A350-1000. The second leg is equipped with Q-Suites, widely reputed to be the best biz class around (spoiler alert: I agree).
787 - KHI to DOH
1-2-1 configuration, we took the middle two seats. The seating was modern, spacious and comfortable. Crew was great. We flew during ramadan and they made a suhoor announcement so that people could start their fast on time (we elected not to fast on that day because we were traveling on an especially long westbound journey). I got up and prayed fajr in the door/galley area between the two biz class cabins. The crew didn't object (though they could have, see later). The restroom was decent (with a window!) with good amenities (including toothbrush/toothpaste). The plane was relatively quiet at 64DBm
We started off on the wrong foot as we had to deplane via stairs, not a jetty so a bit of an issue if you have mobility issues. The airport (once we were bussed to the terminal) is spectacular - huge, ultramodern and great facilities, shops etc. The business class lounge is also great, probably one of the best around.
A350 - DOH to SFO
1-2-1 configuration and again we took the two middle seats in row 1.
Seats/cabin are spectacular - not as wide as Singapore's but otherwise a bit better. The two main standout things are doors from the aisle (so then you are in a pseudo cocoon [still open at the top]) and the seats are close enough together and you're almost in a double bed configuration. The food is great and the service outstanding. Everything is halal (but they do serve booze). They several cameras (including my favorite tailcam) and prayer direction (though, like almost all other systems, it gives the wrong direction near SFO). One thing I found strange was that they ask you to sit in your seat while praying - they are the only airline that explicitly does that and it doubly strange coming from a conservative muslim country. The timing of the westbound flight is such that one doesn't have to pray on the plane at all (despite being 14 hours) but I imagine this being an issue on an eastbound journey It was also very quiet - slightly quieter than the dreamliner.